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David T. Kuhn
Professor Emeritus
Ph.D., Arizona State, 1970
Phone: 407-823-2976
Office: BIO 302A
Email: dkuhn@pegasus.cc.ucf.edu
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Research Interests
ftz-eve double stained D. melanogaster fly embryo |
Emeritus Professor Kuhn is a developmental geneticist who explores the roles played by homeotic genes during embryogenesis. This class of genes causes normal anatomical structures to be expressed in inappropriate locations. These studies are conducted with the fruit fly Drosophila melanogaster as the model organism. His group and his collaborators current interests focus on the role that retrotransposons play in regulating developmental genes. The techniques employed in these studies range from classical genetics to routine molecular techniques, including immunological detection of gene products to quantitative PCR and microarray analysis.
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Selected Publications
Kuhn, D.T., J.M. Charerri, D.A. Persaud, and A. Madjidi 2000. Pair-rule genes cooperate to activate en stripe 15 and refine its margins during germ band elongation in the D. melanogaster embryo. Mechanisms of Development 95: 297-300.
Packert, G., and D.T. Kuhn 1998. The tumorous-head-1 (tuh-1h) locus affects bristle number on the Drosophila melanogaster cuticle. Genetics 148: 743-752.
Mack, J.A., R. Smith, and D.T. Kuhn 1997. Mobile element 297 in the Abd-B gene of the tuh-3 chromosome, not Delta-88 causes the tumorous-head phenotypes in Drosophila. Genetics 147: 679-688.
Freeland, D.E., and D.T. Kuhn. 1996. Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs.
Mechanisms of Development 56: 61-72.
Kuhn, D.T., G. Turenchalk, J.A. Mack, G. Packert, and T.B. Kornberg. 1995. Analysis of the genes involved in organizing the tail segments of the Drosophila melanogaster embryo. Mechanisms of Development 53:3-13
Kuhn, D.T., J.A. Mack, C. Duan, and G. Packert. 1993. Tumorous-head (tuh-1; tuh-3) modulates Abd-B bithorax-complex functions in D. melanogaster. Genetics 133: 593-604.
Kuhn, D.T., M. Sawyer, G. Packert, G. Turenchalk, J.A. Mack, T.E. Sprey, E. Gustavson, and T.B. Kornberg. 1992. Development of the D. melanogaster caudal segments involves suppression of the ventral regions of A8, A9 and A10. Development 116: 11-20.
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