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Research Interests
I am interested in biological and computational approaches to understanding developmental biology. My biological interests have focused on the signaling mechanisms involved in cell migration guidance and fibroblast growth factor (FGF) signal transduction. My laboratory has used molecular-genetic approaches to study the cell migrations of the sex myoblasts and FGF signaling in the nematode Caenorhabditis elegans. My computational interests lie in developing modeling methodologies to represent biological systems, with the goal of enhancing our understanding of these systems via the formalization and integration of the increasingly complex array of available biological data.
Selected Publications - Sadot, A., Fisher, J., Barak, D., Admanit, Y., Stern, M.J., Hubbard, E.J.A. and Harel, D. (2008). “Towards Verified Biological Models.” IEEE/ACM Transactions on Computational Biology and Bioinformatics 5:223-234.
- Lo, T. W., Branda, C. S., Huang, P., Sasson, I. E., Goodman, S. J., and Stern, M. J. (2008). “Different isoforms of the C. elegans FGF receptor are required for attraction and repulsion of the migrating sex myoblasts.” Dev. Biol. 318:268-275.
- Kam N, Kugler H, Marelly R, Appleby L, Fisher J, Pnueli A, Harel D, Stern MJ, Hubbard EJ. (2008). “A scenario-based approach to modeling development: a prototype model of C. elegans vulval fate specification.” Dev Biol. 323: 1-5.
- Huang, P. and Stern, M. J. (2005). "FGF signaling in flies and worms: more and more relevant to vertebrate biology." Cytokine Growth Factor Rev 16: 151-158.
- Fisher, J., Piterman, N., Hubbard, E.J.A., Stern, M.J., and Harel, D. (2005). "Computational insights into Caenorhabditis elegans vulval development." Proc Natl Acad Sci U S A 102: 1951-1956.
- Goodman, S.J., Branda, C.S., Robinson, M.K., Burdine, R.D. and Stern, M.J. (2003) “Alternative splicing affecting a novel domain in the C. elegans EGL-15 FGF receptor confers functional specificity.” Development 130:3757-3766.
- Borland, C.Z., Schutzman, J.L. and Stern, M.J. (2001) "FGF signaling in the nematode Caenorhabditis elegans." BioEssays 23:1120-1130.
- Chen, E.B. and Stern, M.J. (1998) "Understanding cell migration guidance: lessons from sex myoblast migration in C. elegans." Trends Genet. 14, 322-327.
Education - Ph.D. Biochemistry, 1986 - University of California, Berkeley
- B.S. Molecular Biophysics and Biochemistry, 1981 - Yale University
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