|
 |
Research Interests
Dr. Bayer collaborates with the von Kalm laboratory (Department of Biology) to study the hormonal control of Drosophila epithelial morphogenesis. In Drosophila, leg and wing imaginal disc epithelia develop in response to the coordinated activities of the steroid hormone ecdysone and the intracellular Rho1 signaling pathway. Interactions between hormonal signals and intracellular signaling pathways underlie much of animal development, yet the mechanisms used by these signaling networks to coordinate development are poorly understood. Dr. Bayer's research focuses on hormonally-induced proteases and transcription factors that interact with the Rho1 signaling pathway to control the development of imaginal disc epithelia. Her research contributes to the basic understanding of epithelial development and our understanding of the interactions between steroid hormones and intracellular signaling pathways in human pathology.
Selected Publications
Tsen, C., Iltis, M., Bayer, C., Kaur, N., Delcros, J-G., von Kalm, L. and O. Phanstiel (2006) A Drosophila model to screen for polyamine transporter selective agents in an intact epithelium. Submitted to Journal of Medicinal Chemistry.
Bayer, C.A., Halsell, S.R., Fristrom, J.W., Kiehart, D.P. and L. von Kalm (2003) Genetic Interactions Between the RhoA and Stubble-stubbloid Loci Suggest a Role for a Type II Transmembrane Serine Protease in Intracellular Signaling During Drosophila Imaginal Disc Morphogenesis. Genetics 165, 1417-1432.
Bayer, C.A., Zhou, X., Zhou, B., Riddiford, L.M. and L. von Kalm (2003) Evolution of the Drosophila broad locus: The Manduca sexta broad Z4 isoform has biological activity in Drosophila. Development Genes and Evolution 213, 471-476.
Mugat, B., V.Brudo, J. Kejzlarova-Lepesant, C. Antoniewski, C. Bayer, J. Fristrom, and J.-A. Lepesant (2000) Dynamic expression of Broad-Complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis. Dev. Biol. 227, 104-117.
Bayer, C.A., von Kalm, L., and Fristrom J.W. (1997) Relationships Between Protein Isoforms and Genetic Functions Demonstrate Functional Redundancy at the Broad-Complex During Drosophila Metamorphosis. Dev. Biol. 187, 267-282.
Sandstrom, D.J., Bayer, C.A., Fristrom, J.W., and Restifo, L.L. (1997) Broad-Complex Transcription Factors Regulate Thoracic Muscle Attachment in Drosophila. Dev. Biol. 181, 168-185.
Crossgrove, K., Bayer, C.A., Fristrom, J.W., and Guild, G.M. (1996) The Drosophila Broad-Complex Early Gene Directly Regulates Late Gene Transcription During the Ecdysone-Induced Puffing Cascade. Dev. Biol. 180, 745-758.
Bayer, C.A., Holley, B., and Fristrom, J.W. (1996) A Switch in Broad-Complex Zinc-finger Isoform Expression is Regulated Post-Transcriptionally During the Metamorphosis of Drosophila Imaginal Discs. Dev. Biol. 177, 1-14.
Bayer, C.A. von Kalm, L., and Fristrom, J.W. (1996) Gene Regulation in Imaginal Disc and Salivary Gland Development during Drosophila Metamorphosis. In "Metamorphosis: Postembryonic Reprogramming of Gene Expression in Amphibian and Insect Cells" (L.I. Gilbert, B.G. Atkinson and J.R. Tata, Eds.), pp. 321-361. Academic Press.
Bayer, C.A., Curtiss, S.W., Weaver, J.A., and Sullivan, D.T. (1992) Delineation of cis-Acting Sequences Required for Expression of Drosophila mojavensis Adh-1. Genetics 131, 143-153.
DiBello, P., Withers, D., Bayer, C.A., Fristrom, J.W., and Guild, G.M. (1991) The Drosophila Broad-Complex Encodes a Family of Related Proteins Containing Zinc Fingers. Genetics 129, 358-397.
| |
